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Eligibility criteria for selecting studies: Prospective cohort studies with at least 50 events, reporting hazard ratios or relative risks (both hereafter referred to as relative risk) compared with never smokers or age specific incidence in relation to risk of coronary heart disease or stroke

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Chemical neutralization: While brewed coffee is acidic (pH ~5.0), spent, air-dried grounds undergo subtle oxidation, raising their surface pH to 5.56.8